Dr. Alfred Durham, a Kiwanis member, founded the Altrusa Institute in Nashville in 1917 during World War I, recognizing the need for women’s civic organizations. He organized clubs in Nashville, Louisville, and Dayton before meeting Mamie L. Bass in Indianapolis.

Mamie L. Bass, former Superintendent of the Women's Division of the U.S. Employment Services, envisioned a greater purpose for Altrusa. At the first convention in June 1918, Altrusa became a classified service organization for business and professional women, renamed the National Association of Altrusa Clubs. Bass authored the Principles of Altrusa, defining it as “a builder of women,” officially adopted in 1921. By 1922, there were 20 clubs.

Altrusa promoted vocational education for women, later expanding to scholarships and guidance for both young and older women. It became international in 1935 with a club in Mexico and soon expanded to other countries. In 1946, Altrusa sent its first representative to the United Nations.

In 1966, Altrusa founded ASTRA clubs for young women aged 13–21. Literacy became a permanent service focus in 1977, and in 1997, the Altrusa Foundation adopted Camp Safe Haven for children with HIV/AIDS. In 1989, Altrusa added environmental initiatives to its mission.

Today, Altrusa remains a community-based organization dedicated to local service—supporting shelters, youth, literacy, and housing projects. District Seven includes Iowa, Minnesota, Nebraska, North Dakota, South Dakota, Michigan, and Wisconsin.