Frank Charles William Kuehn was born on September 4, 1884, in LeMars, Iowa. His family moved to Dakota Territory when he was just seven months old, settling on a claim in Jackson Township, Sanborn County, on March 1, 1885. The family lived in a sod shanty, surrounded by Kuehn's extended family, including his grandfather and the siblings of his parents, Elizabeth and Frank Theodore Kuehn. In March 1903, the family relocated to Huron, South Dakota, where Kuehn would live for the next 67 years. On June 3, 1914, Kuehn married Amelia Johanna Wagner, and together they had three daughters: Jeannette, Lois, and Margaret. Amelia passed away in October 1950 due to a heart attack, and Kuehn remarried Florence Dokken Hanson on August 15, 1954.

From a young age, Kuehn was determined to become an architect. He enrolled in the International Correspondence Schools in Scranton, Pennsylvania, and in 1907 began working for Huron architect George Issenhuth. He continued working for Issenhuth through 1909 while furthering his studies. On September 9, 1909, Kuehn opened his own architectural office in Huron, SD, and quickly established himself as a school architect with a design for a two-story brick school in Frankfort, SD. This building, a notable example of Prairie-School Style architecture, marked the beginning of his 41-year relationship with the South Dakota Department of Public Instruction.

In 1918, to supplement his income during a decline in building projects due to World War I, Kuehn began selling insurance. He continued this work alongside his architecture throughout his life. In the early 1920s, Kuehn designed homes and notable downtown Huron buildings, and began producing county maps for South Dakota, North Dakota, and Minnesota. In the 1930s, he founded the Huron Blueprint Co., which provided services during the Great Depression. He also worked for the Home Owners Loan Corporation, inspecting homes for financing. During the 1940s, Kuehn’s Standard Rural School Plans gained recognition beyond South Dakota.

In the 1950s, Kuehn shifted his focus almost exclusively to his expanding county map business. By the 1960s, he had broadened his maps to include highway maps for Minnesota counties and compiled books combining maps from South Dakota, North Dakota, and Minnesota, which sold well. Kuehn passed away in 1970 following an illness. Over the course of his career, he designed numerous projects, many of which are detailed in the 1984 publication F.C.W. Kuehn Prairie Architect, written by his daughters, which documents his life and architectural contributions.